BioInterfaces
Team leader BioInterfaces: Prof. Dr. Oya Tagit
Nanoparticles precisely engineered at the nanoscale have emerged as novel therapeutic and diagnostic agents due to their unique physicochemical properties (e.g. optical, magnetic, electronic, etc.) that are dictated by their size, shape, composition, surface; and can be customized for the desired biological targets and functions. With applications ranging from imaging and detection probes to nanocarriers for (bio)therapeutics delivery, engineered nanoparticles can give unprecedented information on the chemical and physical processes that take place in biological systems, and enable targeted therapeutic interventions.
In the group of BioInterfaces, we aim to address currently unmet biomedical needs in the diagnosis, monitoring, and treatment of disease with engineered nanoparticles tailored for the desired biological targets and functions. We utilize an interdisciplinary approach at the interface between materials chemistry, nanotechnology, and biology for bench-to-bedside development of optical and magnetic detection probes, (pre-)clinical imaging agents, and drug delivery systems based on inorganic and polymeric nanoparticles. We study the diagnostic and therapeutic performance of these nanoparticles in vitro and in vivo using advanced imaging and cell culture techniques and disease models.
PhD candidate
Senior Scientist
MSc thesis
Visiting Researcher
Visiting Researcher
M-SLS-MSc 0223 Molecular and Translational Imaging
M-SLS-F Biomarker
In the group of BioInterfaces, we aim to address currently unmet biomedical needs in the diagnosis, monitoring, and treatment of disease with engineered nanoparticles tailored for the desired biological targets and functions. We utilize an interdisciplinary approach at the interface between materials chemistry, nanotechnology, and biology for bench-to-bedside development of optical and magnetic detection probes, (pre-)clinical imaging agents, and drug delivery systems based on inorganic and polymeric nanoparticles. We study the diagnostic and therapeutic performance of these nanoparticles in vitro and in vivo using advanced imaging and cell culture techniques and disease models.
Projects & News
Best Poster Prize for Anamarija Nikoletic
Anamarija Nikoletic, PhD candidate at the Group of Biointerfaces led by Prof. Dr. Oya Tagit, received the best poster prize at the Swiss Nanoscience Institute Annual Event. In her SNI PhD School project entitled “Multi-compartment nanofactories for on-site and on-demand drug synthesis and delivery”, Anamarija aims to develop triggerable, compartmentalized vesicles…
Welcome to Marta Maria Alves Pereira
Marta Maria Alves Pereira PhD candidate Ms Marta Maria Alves Pereira has been awarded a scholarship from the CAPES Foundation, an agency under the Ministry of Education of Brazil, to spend one month at the Group of Biointerfaces led by Prof. Dr. Oya Tagit. Marta will develop and characterize…
Multi-compartment nanofactories for on-site and on demand drug synthesis and delivery
We develop compartmentalized vesicles with internal compartments that can be triggered independently and selectively to release their cargo. Libraries of novel stimuli-responsive block co-polymers are prepared for vesicle formation, and release is actuated by external stimulus such as light, magnetic field, etc.
Nanocarriers for mRNA therapeutics
Combining the stability of polymers with transfection efficiency of lipids, we developed polymer-lipid hybrid nanoparticles, which can be stored as lyophilized powder and display long-term storage stability also in suspension. Lyophilization does not impair transfection efficiency.